Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological objectives and you may pharmacology off curcumin
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the significant component of the fresh new red-colored dye out of turmeric, an Indian liven that’s extracted from the fresh rhizome of one’s exotic plant Curcuma longa, and this is one of the Zingiberaceae nearest and dearest. Within part, i talk about the pharmacological facts of curcumin and you will mention the newest unit bases for those affairs. We upcoming opinion new demonstrated and you may potential systematic uses of curcumin. Curcumin is known typically given that a therapeutic broker, however, its procedure off action was intricate. The brand new pharmacological effects of curcumin appear to be the result of a synergism out of networking sites of poor biochemical interactions having several physiological purpose in interrelated signaling routes. Such needs tend to be nutrients for example cyclooxygenase, lipoxygenase and you will protein kinases, and transcription factors particularly NF-?B, STAT and you may Nrf2. Modulation of them molecules has an effect on downstream affectors that make brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial facts from curcumin. These outcomes had been looked at inside the scientific products out-of curcumin for pain and you can inflammatory sickness, malignant tumors, Alzheimer problem, cardio diseases, and you may diabetes. Brand new products purchased changeable doses of curcuminwith additional frequencies and you will course, with the standard end you to high dosage of curcumin at the quantity of g have to receive therapeutic consequences. Read more
Curcumin: Synthesis, Emerging Role inside the Serious pain Management and you can Health Ramifications
Book Section Samples of plant-derived pharmaceuticals that have end up being the appeal of continuous and you may rapid lookup and innovation attention features, thus far, been somewhat scarce. After several years, the final two decades was indeed characterized by a beneficial 100-flex increase in exactly how many medical posts blogged a year you to was away from significance towards usage of curcumin inside the biomedicine. Read more
Structure, synthesis and you may biological issues out-of curcumin prodrugs
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many possible pharmacological consequences and might provides healing applications a number of disease claims, because the talked about in more detail in the earlier chapter. Yet not, the possibility scientific effectiveness from curcumin is bound of the the physicochemical qualities from terrible water solubility and you can instability, and therefore cause lower bioavailability. Prodrugs off curcumin give an approach to upgrade of your own biopharmaceutical and you will pharmacokinetic features, that can ensure it is exploitation of the pharmacological outcomes of curcumin. Contained in this chapter, i earliest opinion the fresh physicochemical and you can pharmacokinetics away from curcumin. We next describe the design of curcumin prodrugs that have enhanced drinking water solubility and you will increased chemicals balance which are often translated to 100 % free curcumin abreast of bioactivation during the vivo. We emphasize latest achievement in this area, with a concentrate on the construction, synthesis and you may review off prodrugs predicated on promoieties and proteins, efas, nucleic acids, dicarboxylic acids, and polymeric materials particularly hyaluronic acidic and you may polyethylene glycol. Which part gets the reason behind optimization of your own physicochemical and biopharmaceutical functions while the physiological factors from curcumin prodrugs, for the objective playing with of Uzbekistani tjej het them curcumin derivatives into the systematic applications. Read more